What Age does Polycystic Kidney Disease Set in

Healthy kidneys are primarily responsible for filtering the blood, removing waste products and extra electrolytes, and also regulating blood pressure. Polycystic Kidney Disease is a genetic disorder which is marked by the formation of multiple fluid-filled cysts on the kidneys. Over time, the disease may cause that kidneys to function improperly (because the normal kidney tissue is replaced by the cysts), ultimately progressing to end-stage renal disease (ESRD). While, what age does PKD set in?

People cannot catch PKD from a virus or by being exposed to another person who has this disorder. It is hereditary and there are two distinct forms of the disease that are classified based on their inheritance patterns.

▪ Autosomal dominant PKD is by far the most common form of PKD and runs in families, which is passed from parent to child. Children of parents with this disease have a 50 percent chance of inheriting the gene. About 10% of patients have a gene that mutated causing the disease. About half of people with ADPKD progress to Renal Failure.

▪ Autosomal recessive PKD occurs in only about 1 in every 125,000 people. It strikes infants sometimes even before birth. The disease is also called "infantile PKD". Both parents must be carriers of the ARPKD gene to pass it to a child. Children have a 25 percent chance of getting this disease.

ADPKD patients often have no symptoms until they reach between age of 30~40. The most common symptoms include high blood pressure, hematuria (blood in the urine) and/or pain in the back, sides and belly.

While, ARPKD is usually diagnosed very early on. An ultrasound can reveal cysts in a fetus's kidneys, while it is still in the womb. This disease can also affects other areas of the body such as the liver, pancreas, and spleen, causing low blood cell counts, varicose veins and hemorrhoids.
By age of 60, about 50% of PKD patients will need dialysis or a kidney transplant to replace the kidneys' function. Of children with ARPKD, about 1/3 will need dialysis or a transplant by the time of 10-years old.

However, some PKD patients are living a normal life without dialysis, since they receive standard treatment which can help shrink the enlarged cysts, stop the progress of disease, and restore the kidney functions.

Can the Cysts of Polycystic Kidney Disease be Controlled and Shrinked

As is known to us, Polycystic Kidney Disease is an inherited disease which shows the highest incidence in those with family histories. However, at the early stage, the cysts are relatively small and may not be easily found before 20 years old; while from 30 to 40 years old, the cysts enter a fast development stage, during which traditional measures in western medicine are to keep close observation of the cysts and to take according methods in case of symptoms.

For the grown-up cysts, operations such as windowing decompression and pumping liquid and solidification surgery are often taken, which, on the one hand, can relieve the pressure of the cysts on the renal parenchyma and prolong the development the disease; however, on the other hand, the relieved pressure may offer an environment for the remaining cysts to continue growing. Therefore, traditional surgeries can't treat the cysts fundamentally. Then is there any method with which the cysts of Polycystic Kidney Disease can be controlled and shrinked without recurring?

The root of treating Polycystic Kidney Disease is to block the renal fibrosis process caused by the pressure of the growing cysts on renal parenchyma. On this respect, Micro-Chinese Medicine Osmotherapy, which achieves its effects by penetrating the effective Micro-Chinese medicine into the renal lesions with penetrant and infiltration devices, has really done it successfully. In comparison with traditional western medicine, it can avoid the side effects of oral medicines and lead the effective composition of the medicines to the kidneys without bringing new traumas. More exactly, Micro-Chinese Medicine shrinks the cysts by blocking renal fibrosis with its four principle functions of vascular dilation, anti-inflammation, anticoagulation and degradation, which can be seen as follows:

1. Vascular dilation :

It can expand all the renal arteries of Polycystic Kidney Disease sufferers, improve local microcirculatory disorders, increase effective renal perfusion, improve the hypoxia state of the damaged kidneys and fasten the repairing of damaged renal intrinsic cells; moreover, it can expand the vessels on vascular walls around the polycystic kidneys and increase the permeability of cystic walls; reverse the pressure difference between the intravascular pressure and the intracapsular pressure, therefore, the cysts can be shrinked gradually.

2. Anti-inflammation

Eliminate the inflammatory response caused by the damages of renal intrinsic cells as a result of the extrusion of the cysts on the kidneys.

3. Anticoagulation

Eliminate the micro thrombus activated by the coagulation mechanism as a result of the damages of renal intrinsic cells.

4. Degradation

The active substance of the Micro-Chinese Medicine can degradate and excrete the abnormal accumulation of extracellular matrix. Moreover, it can promote the excretion of accumulated immune complex, metabolites, and necrotic tissues.

Besides, the above four measures, the active substance can promote the phynotypic reversion of damaged intrinsic cells and provide necessary repairing substances for damaged renal intrinsic cells. Therefore, Micro-Chinese Medicine Osmotherapy can really achieve the goal of shrinking the cysts of Polycystic Kidney Disease and fastening the repairing process. Finally the symptoms such as hypertension and hematuria will also disappear with its roots diminished.

What Is the Symptoms of PKD in End Stage

Nowadays, more and more people get Polycystic Kidney Disease (hereinafter called PKD), and fat people have higher incidence of PKD because they are likely to get Hypertension and Diabetes. However, PKD does not present special symptoms in the early stage. Once symptoms appear, PKD usually accesses to more severe stages like Renal Failure or Uremia. It is helpful to recognize PKD symptoms in end stage so that patients can make necessary precautions and take treatment properly.


I, cysts enlarge. The volume of cyst increases, and it is 10 times of normal one virtually. Kidneys have paramorphia, for instances, renal pelvis and calices present abnormal shapes; the integral structure of renal papilla and renal pyramid are damaged respectively


II, cysts presents ball and they have different size.


III, Polycystic Kidney enlarge with the cysts, and nephrons are damaged totally. Renal Failure and Uremia can occur successively, renal functions are destroyed virtually.


IV, Hematuria


Hematuria occurs when cysts volume enlarge to cause cysts rupture. The main reasons to cause cysts rupture are probably fierce exercises or over fatigue. In this case, patients need to see the doctor immediately, or else cysts will rupture which arouses the aggravation of disease.


V, Complications occur, let’s say eye-ground lesion. Hypertension arouse eyebase arteriosclerosis, which reduces blood supply to retina; massive Hematuria incurs Hemoglobin B to decrease dramatically which further damages optic nervous lesion and blood supply on the original injuries. At last, secondary optic atrophy happens.


The above passages introduce PKD symptoms in End stage. Patients should take immediate treatment on PKD. In the early stage, patients must not neglect them because of no apparent symptoms, or else it will imperil life with the enlargement of cysts and the treatment will meet many challenges as well.


If you still have other confusion about PKD, you can email me at kidneyfailurecn@hotmail.com.

What are the Causes Polycystic Kidney Disease Proteinuria

Proteinuria is one of the most common symptoms of Polycystic Kidney Disease (PKD). The degree of proteinuria differs very much according to different patients. While, no matter the proteinuria is serious or slight, it is an important index to analyse the kidney disease. Then what are the causes of proteinuria?

The main cause is that the glomerulus filtration film was damaged, which will lead to the increase of its permeability and the leaking of protein. The pathology process is as following: when various pathology damages lead to the obstacle of renal focal microcirculation, they will cause the ischemia and anemia of the kidney. The condition of ischemia and anemia will lead to the damage of blood capillary endothelial cells and blood capillary. Then the damage of blood capillary will attract the invading of inflammatory cells to the blood circulation system. The inflammatory cells may release the inflammatory factors and start the process of renal fibrosis. The inflammation of kidney will cause the pores on the glomerulus filtration film getting bigger or close. Then the permeability of glomerulus filtration film will increase and the protein will leak out.

Then how can we treat proteinuria? To treat the propeinuria effectively and control the development of disease, we must proceed from the causes of proteinuria. There are two key points for the treatment： First, inactivate the inflammatory factors to prevent from the further damage of glomerulus. Second, repair the damaged renal inherent cells and repair the damaged renal function to prevent from the leaking of protein.

As for the first point, western medicine has good effects to inactive the inflammatory factors. With the treatment, the proteinuria will gradually get better. While, as for the repair of renal cells and renal function, we must use Micro-Chinese Medicine to repair the damaged renal cells and renal function. By the two methods we can treat the disease fundamentally.

If you have other questions about PKD and the treatment, please contact us on-line or by email.

Can Polycystic Kidney Disease Take Exercise

Can Polycystic Kidney Disease take exercise? This is a puzzling problem for PKD patients. According to this problem, specialists on Kidney Disease notice that PKD patients can take physical exercise properly and scientifically, but excessive exercise is forbidden. As for PKD patients, which standard of daily exercise and work can not affect their body health? Normally, this depends on patients’ individual illness condition. Generally speaking, there are very few problems before patients are 30 years old. Though cysts of most PKD patients begin to compress each other, the pressure caused by cysts is tiny in this period. So patients can take some safe exercise at this moment, but crashing exercise like basketball should be avoided. Usual light exercise can not affect kidneys normally.

If patients are about 40 years old, they should pay more attention on daily work and life. Because cysts produce larger pressure in this period and strenuous exercise usually bring cyst rupture to patients. For this reason, patients should avoid pressure or collision on kidney region. Especially for a housewife, they should be more cautious when she is looking after a baby in order to prevent baby kicking her kidney region.

As for patients who had suffered from Haematuria before, they are required to pay more attention on their daily activity, because cysts of these patients are much easier to get cyst rupture. In order to prevent Haematuria recurrence, patients should take some exercise with less bending angle and lighter strength burn. Besides, these patients should take chairs with similar height of their knee when they are sitting. Walking and slow run can be taken as main morning exercise.

In a word, PKD patients who want to take some exercise should take a proper exercise volume and avoid excessive activity. Besides, the most important thing is to treat PKD in time and control cysts growing. Only in this way, PKD patients can have a normal life as other healthy person.

more for you: How Long Can A PKD Patient Live on Dialysis

Principles of Daily Life for PKD Patients

As for PKD patients, no matter they are in regular treatment time or in a convalescence stage, they should pay attention to their personal diet and related health care points, which is beneficial for PKD patients to get a relative better prognosis.

Ⅰ. Life care:

Firstly, patients should improve their both mental and physical rest. For example, Nephrotic Hypertension patients should check blood pressure regularly and adjust their bed rest time according to their blood pressure change.

Secondly, proper diet: special diet should depend on different illness conditions. For example, if patients are in Renal Insufficiency period, they should have a diet with proper high calorie and rational high-quality low protein. Besides, liquid intake should also be limited in order to keep water balance.

Thirdly, patients should keep their mouth care after a meal in order to eliminate bad breath, reduce nausea and prevent bacteria and mildew growing.

Fourthly, patients should pay more attention on skin cleanness in order to prevent skin infection. On point should be noticed that patients should avoid soap and alcohol. As for patients who suffer from serious Edema, they especially should care their skin cleanness and change lying position frequently in order to prevent bedsore.

Ⅱ. Mental and psychology:

This refers to adjusting mood and emotion in Chinese Medicine. Kidney Disease has a long course with frequent recurrence, so patients usually have heavy mental burden. For this reason, it is important to encourage patients to talk about their trouble and encourage them to have a healthy emotion and relaxing mind in order to avoid negative emotion.

From the above, we hope that it will be helpful for PKD patients. However, the key to treat PKD is to block Renal Fibrosis and recover injured renal inherent cells, which can control cysts growth effectively and prevent this disease developing into Renal Failure and Uremia.

more for you:Can Patients with PKD in ESRD Avoid Dialysis

Diet Principle for Polycystic Kidney Disease Patients

Polycystic Kidney Disease patients should pay more attention on their daily diet which is a very important aspect in treating Polycystic Kidney Disease. As for diet of Polycystic Kidney Disease patients, some points should be noticed:

Protein limitation: In modern medicine theory, high or low protein ingestion is both harmful to human bodies, especially too much protein intake. High protein intake can produce more metabolic waste, such as urea, creatinine, guanidines and other nitrogenous metabolic wastes, all of which can be found in End Stage Renal Failure and toxin of Uremia.

Due to declined metabolic ability of Kidney Disease patients, besides protein limitation and avoiding greasy food, slated food and spicy food as well as pollutant food should also be avoided. A proper protein intake is beneficial to reduce kidney burden and decrease incidence of End Stage Renal Failure and Uremia, playing a significant role in relieving illness condition.

Salt limitation: salt intake should be limited according to patients’ illness condition and severity of renal function injury. But not all Kidney Disease patients need salt limitation.

Water ingestion: due to declined renal concentrated function, metabolic waste can be excreted out of human body with more water supply. If patients do not have obvious symptoms of Edema, Heart Failure and High Blood Pressure, they should take in water scientifically.

Generally speaking, Polycystic Kidney Disease patients should avoid salted food, spicy food, polluted food as well as broiled dishes. If patients’ illness condition has developed into Renal Failure or Uremia, patients should also avoid beans and bean production.

more for you: Can I Shrink Cysts in PKD with a Diet

Food that Can Drop the Blood Pressure

There are a variety of symptoms of the disease of Polycystic Kidney Disease (PKD), and hypertension is one of the common symptoms of this disease. Except the regular medicine treatment, many kinds of food have the function of dropping blood pressure.

First, fruit:1, apples, containing abundant organic acid, fructopyrancose, pectin, cellulose and many kinds of trace elements, such as lithium, bromine, zinc and so on, have the functions of preventing angiosclerosis, preventing and treating arteriosclerosis and coronary heart disease. According to the recent years’ research, eating more apples is especially good for the hypertension patients who like taking in too much salt.

2, watermelon: containing more than ten kinds of nutrient, watermelon has good effects on treating hypertension. Both the peel and seed of watermelon can be used.

3, fresh plum: plums are rich in acid, citric acid, malic acid, succinic acid and other nutrient substance. As for hypertension patients who have the symptoms of swirl, insomnia, they can use some blackberry of many years’ standing and stew them with proper boiling water, then take in the water and plums, which has the functions of dropping blood pressure, clearing heat and promoting fluid.

4, lemon: it is rich in vitamin C and P. so lemons have the functions of increasing the elasticity and toughness of the blood vessels, remitting the calcium ion and promoting the blood clotting, preventing and treating hypertension and other cardiovascular diseases.

Second, medicine porridge: 1, carrot porridge: cut up 120g fresh carrot and boil it with 100g polished round-grained rice.

2, celery porridge: cut up 90g celery, together with the root of celery, and then boil it with 100g polished round-grained rice.

3, garlic porridge: put 30g peeled garlic into the boiling water. One minute later, fish the garlic out and then put 100g rice into the same water. After the rice having been boiled, put the boiled garlic into the porridge for a while. Then you can enjoy it.

4, lotus leaf: boil the lotus leaf with 100g rice and you can take it as a common meal.

Third, an effective folk remedy for hypertension: make the one egg boiled. Peel the egg white and eat it. Then put the egg yolk in a bowl and smash it into powder. Then add proper vinegar to it. Mix them up and take in. long-term taking can drop the blood pressure.

Dietary therapy is one method of Chinese medicine and it is also a method of natural treatment. On one hand, it can treat disease. Meanwhile the patients can enjoy the delicious and healthy food. What a wonderful thing it is.

The Hazards of Proteinuria Caused by Polycystic Kidney Disease

Proteinuria is one of the most common symptoms of the disease of Polycystic Kidney Disease (PKD). The hazards of the proteinuria are not just the serious drain of the protein nutrition. Proteinuria will also cause the damage to the glomerulus and kidney tubules, thus it can cause the fibrosis of kidney. according to the clinical researches, proteinuria is one of the independent factors which can cause uremia. The greatest hazard of proteinuria is to corrode the kidney tissues and t cause uremia. Then what are the specific hazards of proteinuria?

First, proteinuria has the mesentery toxicity: in the model of renal failure, we can observe that the haemocyanin will accumulate in the glomerulus mesentery, which will cause the damage to the mesentery cells and the hyperplasia of the mesentery cells and the increase of combining of the various mesentery matrix, thus proteinuria can cause the hardening of the glomerulus. Besides, when there are low density lipoprotein and very low density lipoprotein in the glomerulus, the deposition of the apoprotein A and B will gradually lead to the hardening of glomerulus.

Second, proteinuria has the toxins to the proximal convoluted tubule cells: when there is the symptom of pproteinuria, the amount of protein entering the kidney tubule epithelial cells will increase, which will lead to the increase of lysosome activity and cause the lysosome spill into the cytoplasm of kidney tubules. And then subsequent damage to cells may cause the infections and the forming of scar.

Third, proteinuria may cause the cytobiology changes of the kidney tubules: protein can recuperate the function of kidney tubules directly and change the growth characteristic of the kidney tubules. The change of the protein phenotype may cause the kidney tubules basement release PDGF、FN andMCP-1, and then cause the renal fibrosis.

Forth, proteinuria may cause the aggravation of the anoxia of kidney tubules mesenchyme: the adsorption of the protein needs much extra energy, which will cause the anoxia of kidney tubules.
Therefore, protein is not just a symptom of Polycystic Kidney Disease. At the same time, it will cause various damages to the kidney tissues and kidney function.

How to treat occult blood caused by PKD

There are various complications of polycystic kidney disease (PKD) with the enlargement of cysts. Occult blood is one of the most common complications of PKD, caused by the rupture of large cysts. Many patients didn’t find it until they had a physical examination after the appearance of hematuria. And most PKD patients will have occult blood repeatedly, which is hard to treat. There following information is about the treatment of occult blood. Hope it is helpful for you.

Usually, occult blood can be controlled after 4-8 days by taking some medicine. But very soon, it will reappear, especially for patients with anemia whose bleeding is difficult to control. If the occult blood can’t be treated timely, the platelets will reduce, causing anemia. And blood clotting mechanism will decline. If the condition is very severe, the patients may have shock or they may suddenly die caused by bleeding of all the organs. As for the patients with severe anemia, when occult blood appears, it is useless to supplement blood. So, timely treatment for occult blood is very important to the patients.

The bleeding of patients of PKD should be treated comprehensively. When hematuria appears, it may easy cause renal infection, such as, high fever, systemic edema, renal enlargement or even damage of renal function. During the treating of hematuria, anemia should also be treated to increase the number of platelets.

Then how to treat occult blood caused by PKD fundamentally? It’s recommended to combine the weatern medicine with Micro-Chinese Medicine Osmotherapy. After the treatment of western medicine aiming at the symptoms, the occult blood and hematuria may get controlled. Then we should adopt the Micro-Chinese Medicine Osmotherapy to reapir the damaged renal inherent cells and damaged renal function. For Micro-Chinese Medicine has four effects: enlarging blood vessels to improve blood circulation, anticoagulation, anti-inflammation, degradation. As for PKD, this therapy can control the enlargement of cysts and contract the cysts, by which it can prevent the occult blood from the resource. Therefore, after the treatment of Micro-Chinese Medicine, the occult blood seldom recurs.

If you have other questions about Micro-Chinese Medicine Osmotherapy, just contact us on-line or by email: kidneyfailurecn@hotmail.com.

How to Treat Hypertension Caused by PKD

As hypertension is a common symptom of Polycystic Kidney Disease (PKD) and if it can’t be controlled well, it will aggravate the illness condition. Therefore, effective treatment for hypertension is very important. Then how to treat hypertension effectively? Chinese medicine has its unique effects on treating hypertension. On one hand, Chinese medicine has no side-effects and it is very safe. On the other hand, as for the treatment of hypertension caused by this disease, the key point is to treat the cysts. By Chinese medicine treatment, it can relieve the compression of cysts to renal failure and reduce the damage to renal function. Then how does Chinese medicine achieve these treatment effects on treating hypertension caused by Polycystic Kidney Disease?

On the basis of traditional Chinese medicine, we developed out Micro-Chinese Medicine Osmotherapy, which is more effective than the traditional Chinese medicine. By external application, this therapy has its unique functions on treating hypertension caused by this disease. These functions include dilating renal blood vessels, increasing the blood perfusion of the kidney. At the same time, this therapy can improve the systemic micro-circulation of the human body, increase the oxygen supply and enhance the immunity. By all of these, this therapy can enhance the cytoactive of cysts wall, enhance the permeability of cysts wall and eliminate the cysts liquid. Meanwhile, this therapy can prevent from the secretion of cysts liquid and contract the cysts fundamentally.

Besides, this therapy can increase the vasodilatation factors which will promote the blood circulation of the cysts wall. With the function of the Chinese medicine, this therapy can relieve the compression of the cysts to surrounding renal tissue, relieve the ischemia and anemia condition of renal tissues and delay the progression of renal fibrosis. Therefore, Micro-Chinese Medicine can solve the fundamental cause of hypertension.

Creatinine Levels in Blood (Serum Creatinine)

Creatinine in blood is also called serum creatinine. It is a chemical waste molecule that is generated from muscle metabolism. Therefore it is closely related to the amount of muscles. It will not easily affected by diet. A minority of creatinine in blood comes from protein that people have eaten, which do not affect creatinine in blood greatly. Creatinine in blood is one of the important clinical indicators of renal function.

What does it indicate if creatinine level is high in blood?

Creatinine level in blood indicates the degree of kidney parenchyma damage clearly, but it is not a sensitive indicator. It is due to the reason that creatinine level in blood begins to decline when GFR decreases to one-third of normal people’s. Then creatinine level in blood will increase. Kidneys have strong metabolic capacity. This is why people will not have feelings about it when damage of kidney function is not serious.

What are the reasons of increase of creatinine level in blood?

1. Fatigue can cause temporary increase of creatinine level in blood.

2. If concurrent infection including cold, pneumonia, intestinal tract infection and urinary tract infection presents in people with renal dysfunction, creatinine level in blood can increase in short time.

3. Body loses more water can be one of the causes. Fever, little water intake will cause pachemia when you are in diuretic phase. Reducing of blood flow volume of kidney could cause increase of creatinine level in blood.

4. People with kidney diseases take some medication that is toxic to kidney. Creatinine level in blood can increase and sometimes it can not be reversed.

5. The relapse of kidney diseases, Oliguria even anuria may present, acute renal dysfunction can be accompanied. Then creatinine level in blood can increase.

6. If there is hypertension, creatinine level in blood can increase gradually if your blood pressure is not controlled well and moderate or large quantity of proteinuria (urine protein is more than 1 gram or even 1.5 gram) presents for a long time.

If your creatinine level in blood has increased, don't panic, sometimes it will decrease itself. But it is better to have a physical examination and get the diagnosis in time. In some cases, timly treatment of high level of creatinine in blood is suggested to prevent serious conditions.

learn more:What Does Creatinine 4.8 Mean And How to Lower It