Polycystic Kidney Disease: Does Hypertension Cause Cyst Rupture

More than 50 percent of Polycystic Kidney Disease cases will suffer from Hypertension before their 30 years of age. Hypertension always promotes the progression of kidney damages.
Does high blood pressure cause cyst rupture?

From clinic data, we find that patients with high blood pressure tends to cyst rupture earlier than those who’s blood pressure is lower. What’s the relationship between them?

In fact, when renal cysts grow up enough, especially, when they are larger than 3cm, they will oppress nearby kidney tissues, leading to renal ischemia. If untreated, PKD will develop into renal failure very soon.

When renal ischemia occurs, kidneys will secrete a series of hormones. One of them is known as renin. This is the initial substances that activate renin-angiotensin system to rise blood pressure.
Renin-containing cells exist in attenuated arteries in the cyst wall and in cells in the lining tissues around cysts. Besides, inside the cysts walls, there is a layer of epithelial cells which also can increase the quantity of renin. In addition, the active renin is usually present within the cyst fluid.
Renin is proven to promote epithelial cell hyperplasia.

Epithelial cell hyperplasia

Epithelia cells are the birthplace of the cyst fluids. In other words, these cells generate cyst fluids which enlarge cysts day and night. Epithelial cell hyperplasia caused by hypertension will increase the ability to enlarge cysts. This is why hypertension patients are easy to suffer from cyst rupture  than others.

Hypertension prevention

The degree of early hypertension varies with the degree of structural change, as patients with normal serum creatinine with an elevated blood pressure tend to have a higher total cyst volume than those who are normotensive.

Chinese herbs are suggested to prevent hypertension and lower high blood pressure naturally. Meantime, they can shrink renal cysts naturally, thus avoids the cyst rupture.

Hypertension is a sign to kidney damages caused by cysts. If you find your blood pressure increasing, you are suggested to take measures immediately. Otherwise, the further kidney damages may disturb your normal life forever.